More Reasons States Should Not Legalize Marijuana: Medical and Recreational Marijuana: Commentary and Review of the Literature

By: Samuel T. Wilkinson, MD
Nov-Dec 2013

Abstract

Recent years have seen substantial shifts in cultural attitudes towards marijuana for medical and recreational use. Potential problems with the approval, production, dispensation, route of administration, and negative health effects of medical and recreational marijuana are reviewed. Medical marijuana should be subject to the same rigorous approval process as other medications prescribed by physicians. Legalizing recreational marijuana may have negative public health effects.

Introduction

Recent years have seen a cultural shift in attitudes towards marijuana. At the time of this writing, medical marijuana is legal in 20 states and the District of Columbia; recreational marijuana is now legal in Washington and Colorado. A substantial and growing literature documents legalized marijuana may have adverse effects on individual and public health.

Medical Use of Marijuana

The term ‘medical marijuana’ implies that marijuana is like any other medication prescribed by a physician. Yet the ways in which medical marijuana has been approved, prescribed, and made available to the public are very different from other commercially available prescription drugs. These differences pose problems unrecognized by the public and by many physicians.

Lack of Evidence for Therapeutic Benefit

In the United States, commercially available drugs are subject to rigorous clinical trials to evaluate safety and efficacy. Data appraising the effectiveness of marijuana in conditions such as HIV/AIDS, epilepsy, and chemotherapy-associated vomiting is limited and often only anecdotal.1,2 To date, there has been only one randomized, double-blind, placebo- and active-controlled trial evaluating the efficacy of smoked marijuana for any of its potential indications, which showed that marijuana was superior to placebo but inferior to Ondansetron in treating nausea.3 Recent reviews by the Cochrane Collaboration find insufficient evidence to support the use of smoked marijuana for a number of potential indications, including pain related to rheumatoid arthritis,4 dementia,5 ataxia or tremor in multiple sclerosis,6 and cachexia and other symptoms in HIV/AIDS.2 This does not mean, of course, that components of marijuana do not have potential therapeutic effects to alleviate onerous symptoms of these diseases; but, given the unfavorable side effect profile of marijuana, the evidence to justify use in these conditions is still lacking.

Conclusion

There is some evidence that compounds naturally found in marijuana have therapeutic benefit for symptoms of diseases such as HIV/AIDS, multiple sclerosis, and cancer. If these compounds are to be used under the auspices of ‘medical marijuana,’ they should undergo the same rigorous approval process that other medications prescribed by physicians, including randomized, placebo- and active-controlled trials to evaluate safety and efficacy, not by popular vote or state legislature. Furthermore, these therapeutic compounds should be administered via a route that minimizes long-term health risk (i.e., via oral pill) and should be dispensed by centrally regulated pharmacies to ensure the purity and concentration of the drug and allow for the recall of contaminated batches.

Marijuana for recreational use will have many adverse health effects. The drug is addictive, with mounting evidence for the existence of a withdrawal syndrome. Furthermore, it has been shown to have adverse effects on mental health, intelligence (including irreversible declines in cognition), and the respiratory system. Driving while acutely intoxicated with marijuana greatly increases the risk of fatal motor vehicle collision. Legalization for recreational use may have theoretical (but still unproven) beneficial social effects regarding issues such as domestic criminal justice policy, but these effects will not come without substantial public health and social costs. Currently there is a lack of resources devoted to educating physicians about this most commonly used illicit substance. The potential benefits and significant risks associated with marijuana use should be taught in medical schools and residency programs throughout the country.