A Type of Sugar to Treat Fibromyalgia & Chronic Fatigue Syndrome?

By Adrienne Dellwo
Medically reviewed by Grant Hughes, MD 
February 01, 2020

D-ribose is a supplement that's sometimes recommended as a treatment for people with fibromyalgia and chronic fatigue syndrome. Also called ribose or Beta-D-ribofuranose, it's a type of sugar that your body produces naturally and is readily available in supplement form.

D-ribose plays several important roles in your body, such as:

- Helping produce energy in the form of ATP (adenosine triphosphate)

- Serving as a building block of the genetic material RNA (ribonucleic acid)

- Helping increase your muscle energy

As with most supplements, we don't have enough high-quality research to draw a lot of conclusions about it as a treatment for these conditions.

D-Ribose for Fibromyalgia & Chronic Fatigue Syndrome

We have very little research on d-ribose supplementation for either fibromyalgia or chronic fatigue syndrome. Still, some health-care providers recommend it, and some people with these conditions say it is an effective part of their treatment regimen.

One small study published in The Journal of Alternative and Complementary Medicine concluded that d-ribose supplementation significantly improved symptoms of these conditions, including:

• Increasing energy levels
• Improving sleep quality
• Improving mental clarity
• Lowering pain intensity
• Improving overall well being

However, this work is preliminary and we need considerably more research to confirm the findings, including larger studies.

It's unclear how d-ribose accomplishes the things that have been attributed to it. For example, the low energy in fibromyalgia and chronic fatigue syndrome is theorized to come from a deficiency of ATP, but we don't have any proof so far that d-ribose supplementation boosts ATP.1

D-ribose has been theorized to increase exercise capacity and energy following a heart attack, raising questions about whether it can help with exercise tolerance in other instances. It's been studied for increasing high-intensity exercise capacity in athletes but was found to provide no benefit.2 So far, we don't have evidence one way or the other whether d-ribose is effective against post-exertional malaise (a severe symptom increase after exercise), which is a key symptom of chronic fatigue syndrome.

A 2017 review of dietary modifications for chronic fatigue syndrome published in an Australian and New Zealand medical journal noted positive outcomes had been seen with d-ribose in human trials.3

One extremely small study suggests that d-ribose may lessen symptoms of restless legs syndrome, which is common in people with fibromyalgia.4

Again, not nearly enough research has been done, and it doesn't appear to be an area of ongoing interest in the research community. Unless interest picks up, we may never really know whether d-ribose supplements are a safe and effective treatment for these conditions.