Ready to leave?
Oops ! Condition name you have entered is invalid.
You are now leaving Aposbook.com and going to an external site managed by another organization.
Please confirm your email address and try to login again.
This account has been deleted. do you want to restore it?
A verification link will be sent to within the next 2 minutes. Please click it to validate your e mail.
*If you didn't get the link, please check your spam folder
As a registered user, you can benefit from the various free tools and services that we provide.
All you need to do is log in to start discussing with others, interacting, asking questions, and sharing your point of view about the various topics.
You can also write reviews and testimonials about any natural solution you have tried and share your experience. Your feedback can be very helpful.
If you are a health expert, you can add information about any topic or suggest text edit. You can also publish content, including articles and videos, about any topic from the related library section.
Together we can help.
The Aposbook Team
A validation link will be sent to you by email. Please confirm your address to log in
*If you didn't get the link, please check your spam folder
Please log in to use this feature
Your account has been suspended because you have violated our code of conduct. If you think this was a mistake, you can contact us by email at: support@aposbook.com "Contact us" form.
Success! Thank you for your feedback. Your contribution can make a difference. Together we can help each other.
A. J. van Ballegooijen and J. W. Beulens
2017
Abstract
Purpose of Review
Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.
Recent Findings
Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.
Summary
Assessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.
Conclusions
Overall, observational studies indicate that vitamin K has a potential role in cardiovascular health particularly in high-risk and chronic kidney disease populations. Vitamin K intervention trials with subclinical cardiovascular endpoints are scarce. Most clinical studies investigated the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation. Vitamin D may preserve vitamin K-dependent protein activity and can thereby contribute to vascular health. Assessing vitamin K status using multiple biomarkers in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and CVD.