January 2022

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. 

Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. 

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00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge 
01:09:52 Options for Subscription and Support


The Sinclair Lab website: https://sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb
Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h
Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I
Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b
NAD and cancer in mice: https://go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: https://bit.ly/3o10hom
Quercetin and fatty liver disease: https://bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt
Berberine and metabolic disorders: https://bit.ly/3KUpwCC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.