Jul 22, 2019

How Fish Oils work? How Omega 3's work? How do Omega 3 Fatty Acids work? All of these questions are asking the same thing! Fish Oils = Omega 3 Fatty Acids. Fish Oils are used to treat Hypertriglyceridemia or high triglyceride levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks. 


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This pharmacology lecture covers topics such as Fish Oils , Omega 3's, pathophysiology of hypertriglyceridemia, regulation of LDL, HDL, Triglycerides and other complications of bad cholesterol buildup. Mechanism of action of fish oil drugs and their side effects. Drugs mentioned include; Lovaza, Vascepa and over the counter fish oils.


Other theorized Mechanism of Actions for Fish oils:

The mechanism of action of LOVAZA is not completely understood.

Potential mechanisms of action include inhibition of acyl CoA:1,2-diacylglycerol acyltransferase, increased mitochondrial and peroxisomal β-oxidation in the liver, decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity. Fish Oils may reduce the synthesis of triglycerides (TGs) in the liver because EPA and DHA are poor substrates for the enzymes responsible for TG synthesis, and EPA and DHA inhibit esterification of other fatty acids. 

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