Jan 21, 2020
Yun Gao , Liu-Fu Cui , Yuan-Yuan Sun, Wen-Hao Yang, Jie-Rui Wang, Shou-Ling Wu, Xiang Gao
Abstract
Objective: Although several individual nutrients/foods are associated with uric acid status, the association of overall diet quality with hyperuricemia remains unclear. We thus examined the association between adherence to the dietary approaches to stop hypertension (DASH) diet and odds of having hyperuricemia in a Chinese adult population.
Methods: Included were 71,893 Chinese participants of the Kailuan Study I and the Kailuan Study II (mean age: 51.4 y), free of gout prior to or in 2014. Dietary intakes were assessed using a validated food frequency questionnaire and the DASH score was calculated based on consumptions of vegetables, fruit, dairy, beans, whole grains, meat, fat, sodium and sugar-sweetened beverage.
Fasting blood samples were collected in 2014 and hyperuricemia was defined as serum uric acid concentrations of ≥7mg/dl for men and ≥ 6mg/dl for women.
Association between the DASH score and hyperuricemia was assessed using multiple logistic regression models, adjusting for age, sex, total energy, obesity, physical activity, education, smoking, alcohol drinking, blood pressure, fasting glucose, lipid profiles, renal function and presence of cardiovascular disease.
Results: High DASH score was associated with low odds of having hyperuricemia (adjusted OR for quartile 4 vs. quartile 1=0.70; 95% CI, 0.66 to 0.75; P-trend <0.001), after adjusting for potential confounders.
The association between the DASH diet and hyperuricemia was more pronounced among older people (≥50 y), women and physically inactive participants, compared with their counterparts (p-interaction <0.01 for all).
Conclusion: The DASH diet was associated with a low likelihood of having hyperuricemia in Chinese adults.
