May 2016
Anna Dorothea Höck
Abstract
The aim of this report is to review the effects of vitamin D-deficiency on chronic mineral deregulation and its clinical consequences. Recent research data are presented including the effects of vitamin D3-induced calcium sensing receptor (CaSR), fibroblast growth factor 23 (FGF23), the cofactor of FGF1-receptor α-klotho (αKl) and the interplay with each other and with vitamin D3-repressed parathormone (PTH).
The importance of persistent calcium- and phosphate deregulation following long-standing vitamin D3-deficiency for cellular functions and resistance to vitamin D3 treatment is discussed. It is proposed that chronic fatiguing illnesses might be result from mineral deregulations that are barely detected by routine laboratory workups because of compensatory changes in bone mineral stores.
