You might have heard Alzheimer’s disease described as “Type 3 Diabetes,” implying that it’s another “disease of civilization,” a consequence of the modern diet and lifestyle more than anything else. The “Diabetes” label in particular makes it seem like Alzheimer’s is all about the carbs. But it’s actually more complicated than that (isn’t it always?).

Alzheimer’s Disease probably does have something to do with dietary carbs, but it’s much more complicated than “insulin wrecks your brain.” And it also has connections to other parts of the modern diet, especially overload of Omega-6 fats. So here’s a look at Alzheimer’s from a Paleo perspective, focusing on the potential role of diet in long-term prevention and therapy.

This post is not an explanation of how to “cure” Alzheimer’s Disease, or even what causes it, and if you meet anyone trying to tell you either of those things, they’re probably lying. It’s just a look at some possible connections between diet and Alzheimer’s.

What Is Alzheimer’s Disease?

Alzheimer’s Disease is a progressive, age-related brain disease that starts off by causing forgetfulness and confusion and progresses to more serious problems like mood, language, and behavioral issues. A few people get it earlier, but it’s primarily found in people in their 60s and up.

Alzheimer’s isn’t just an extension of normal age-related forgetfulness, though. In Alzheimer’s Disease, neurons in the brain actually die – this doesn’t happen in normal aging, even though most people’s brains do shrink a little bit with age.

In most cases of Alzheimer’s, nobody’s really sure what causes it – we can identify hallmark signs of the disease (amyloid-beta plaques and tangled proteins) and certain genes that make people more susceptible, but there’s no one thing that anyone can point to and definitively claim that it’s what “causes Alzheimer’s.”

As populations in most Western countries get older, Alzheimer’s is becoming an increasingly important health concern, especially because it’s connected to some other rapidly-growing “epidemics:” obesity and diabetes. The association with other notorious “lifestyle diseases” implies that Alzheimer ’s Disease might share some of the same dietary and lifestyle roots.

Alzheimer’s Disease as “Type 3 Diabetes?”

The biggest diet-related risk factor that everyone in the Paleo world likes to point out for Alzheimer’s is diabetes. People with diabetes are much more likely to develop Alzheimer’s than the general population, and it’s likely that this is a consequence of the diabetes itself (not just an association). Diabetes is primarily a disease of glucose (carbohydrate) metabolism, and there’s strong evidence that impaired glucose metabolism in the brain plays a role in the development of Alzheimer’s by depriving cells of energy. If your brain cells are dependent on carbs for energy, but your ability to metabolize carbs is compromised, your brain cells aren’t going to do very well. What’s more, some initial research suggests that ketogenic diets (which provide the brain with fat instead of glucose as fuel) may be helpful as a therapy.

This particular problem even has a name: “Type 3 Diabetes” is the insulin resistance in the brain associated with Alzheimer’s Disease. (if you need a brush-up on insulin, glucose metabolism, and other related issues, here’s a quick explanation of what insulin is, and here’s an overview of what “glucose tolerance”/”carbohydrate tolerance” actually means and why it’s important.)

Another piece of evidence supporting the “Type 3 Diabetes” theory is that other known risk factors associated with Alzheimer’s are also directly or indirectly connected to impaired glucose metabolism. Risk factors for Alzheimer’s include…

- Sleep apnea (a sleep disorder where the patient wakes up many times during the night; it reduces the benefits of sleeping and deprives the brain of oxygen). Sleep apnea reduces insulin sensitivity and increases the risk of metabolic disorders like diabetes, so it might contribute to Alzheimer’s by messing up glucose metabolism even more.

- Physical inactivity. Regular movement makes for good glucose tolerance; a sedentary lifestyle is one big step towards the opposite, so it’s not surprising that it’s a major risk factor for both diabetes and Alzheimer’s.

- Depression. Insulin metabolism problems may contribute to depression, so depression may be one sign of a less-than-optimal insulin metabolism.

- Obesity. Obesity and diabetes often go hand in hand – they’re both associated with problems metabolizing carbohydrates.

- Smoking. Smoking impairs insulin sensitivity, and quitting improves it.