Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

November 2019

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. 
 
Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. 
 
Dr. Sinclair obtained his doctoral degree in molecular genetics at the University of New South Wales, Sydney, in 1995. Since then, he has been the recipient of more than 25 prestigious honors and awards and in 2014 was named as one of TIME Magazine’s 100 most influential people in the world. Dr. Sinclair recently authored the book, Lifespan: Why We Age – and Why We Don't Have To. https://www.simonandschuster.com/book...

In this episode, Dr. David Sinclair discusses exciting new findings in the field of aging research, with special emphasis on the roles of sirtuins, resveratrol, and NAD+.

- Learn more about sirtuins in this overview article
https://www.foundmyfitness.com/topics...

- Learn more about resveratrol in this overview article https://www.foundmyfitness.com/topics...

- Learn more about various forms of fasting in this overview article https://www.foundmyfitness.com/topics...

- Learn more about NAD+ in this overview article.
https://www.foundmyfitness.com/topics...

- Learn more about nicotinamide riboside in this overview article
https://www.foundmyfitness.com/topics...

- Learn more about nicotinamide mononucleotide in this overview article.
https://www.foundmyfitness.com/topics...

Chapters:
00:00:00 - Introduction 
00:00:36 - Activating longevity genes
00:05:02 - Sirtuin activation
00:07:19 - Fasting, caloric restriction, and exercise
00:10:56 - NAD+ 
00:16:00 - Resveratrol 
00:20:00 - Epigenetics
00:36:22 -  Boosting NAD+ 
00:41:11 - Excess calories accelerates 
00:44:26 - Resveratrol slows aging
00:51:00 - NR & NMN in aging
01:00:05 - Sleep improves glucose metabolism