June 2019
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7 Benefits of Using Collagen Daily - Thomas DeLauer
Skin Health
A study, published in Skin Pharmacology and Physiology, had 114 women aged 45-65 years were randomized to receive 2.5 g of collagen or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group
Found that women who took collagen regularly for 8 weeks saw a 20% reduction in wrinkles
Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the collagen-treated volunteers compared to the placebo-treated patients was detectedt
For fibrillin, a 6% increase could be determined after collagen treatment compared to the placebo
https://www.ncbi.nlm.nih.gov/pubmed/2...
Procollagen I is capable of stimulating the production of type I and type III collagen and fibronectin
Elastin is a key extracellular matrix (ECM) protein that provides resilience and elasticity to tissues and organs
Fibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue
Joints
Study - Journal of Agricultural and Food Chemistry
Joint pain in the subjects (80) had been present for 3 months or longer at enrollment
Subjects were divided into two groups and administered either 2 g of collagen or placebo for 70 days
The tolerability profile of the treatment group was comparable to that of the placebo. Intent-to-treat analysis showed that the treatment group, as compared to placebo, had a significant reduction of pain on day 70
The collagen group experienced a significant improvement in physical activities compared to the placebo group on days 35 and 70
https://www.ncbi.nlm.nih.gov/pubmed/2...
Sleep
Glycine is the primary amino acid in collagen, making up about 33% - it helps lower body temperature - glycine works to increase blood flow to the body’s extremities, which reduces core body temperature via vasodilatation (through the activation of NMDA receptors in the SCN shell)
Important as our body operates a process called thermoregulation on a 24-hour circadian cycle, as does the sleep-wake cycle that allows it to adjust core temperature
Our body temperature slightly decreases at night as a slight drop in body temperature is needed for the body’s physical progression into sleep
*Our thermoregulatory system is abolished during rapid eye movement sleep (REM), due to a loss of thermosensitivity in the majority of the hypothalamic preoptic neurons.
Thermosensitivity during REM is not completely depressed; however, sensitivity to hot or cold stimulation is reduced in REM compared to non-REM and wakefulness
The suggested bedroom temperature should be between 60 and 67 degrees F for optimal sleep
Glycine as a sleep promoter, specifics:
The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus
Glycine also inhibits the activity of orexin neurons, which are critical for arousal, energy homeostasis, and reward-seeking
Liver Health
Glycine along with L-taurine are necessary for the synthesis of bile salts
Glycine deficiency may reduce the liver’s ability to synthesize bile - Bile acts as an emulsifier to fats, and is essential for the digestion of fat and fat-soluble vitamins
Bile is also important to inhibit pathogenic bacterial overgrowth, such as clostridium and candida albicans
In studies, glycine has shown to be a therapeutic immuno-nutrient for alcoholic liver disease
https://www.ncbi.nlm.nih.gov/pubmed/1...
Hormonal Balance
Glycine can potentially help in menopause because of its estrogen-like bone protective effects
A study from the journal Amino Acids investigated the estrogen-like osteoprotective effects of glycine (a main ingredient of placenta) in in vitro and in vivo models of menopause
Glycine induced the up-regulation of estrogen receptor-β mRNA expression - moreover, glycine significantly increased the serum 17β-estradiol levels reduced by ovariectomy
https://www.ncbi.nlm.nih.gov/pubmed/2...
Recovery
Two main processes for healing torn or ruptured muscles: regeneration of muscle fibers simultaneously with the production of connective scar tissue.
The key to both of these processes is collagen formation.
In a study by Europe PMC, measuring the rates of collagen protein production for 3 weeks after a muscle rupture, scientists found collagen synthesis rates to be heightened in muscle cells during this time
Brain Health
It’s been found that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta (Aβ) proteins, which are widely thought to cause Alzheimer's disease (AD)
